林泓域/Hongyu Lin
副教授、博士生导师
电话：86-592-2181963
办公室：卢嘉锡楼542室
电子邮箱：hylin007@xmu.edu.cn
课题组网页：https://jhgao.xmu.edu.cn/
个人简历：
学士（南京大学旧版云顶国际yd222，2003-2007）
博士（美国Brandeis University化学系，2007-2012）
博士后（美国Cornell University化学与化学生物学系，2013-2015）
副教授（旧版云顶国际yd222化学生物学系，2016-）
化学生物学福建省重点实验室固定成员。主持国家自然科学基金重大研究计划培育项目、面上项目、青年基金项目、厦门市青年创新基金项目、福建省自然科学基金面上项目等，参与编写全国高等学校教材《临床分子影像检测技术》，授权中国发明专利2项。
研究兴趣：
磁共振造影剂；19F磁共振探针；19F代谢标记；分子探针；肿瘤诊疗
近期主要代表论著：
# co-first authors, * corresponding authors
1. Lin, H.; Tang, X.; Li, A.; Gao, J.* Activatable 19F MRI Nanoprobes for Visualization of Biological Targets in Living Subjects. Adv. Mater. 2021, 33, 2005657.
2. Sun, C.#; Lin, H.#; Gong, X.; Yang, Z.; Mo, Y.; Chen, X.; Gao, J.* DOTA-Branched Organic Frameworks as Giant and Potent Metal Chelators. J. Am. Chem. Soc. 2020, 142, 198-206.
3. Liu, K.; Cai, Z.; Chi, X.; Kang, B.; Fu, S.; Luo, X.; Lin, Z.-W.; Ai, H.*; Gao, J.*; Lin, H.* Photoinduced Superhydrophilicity of Gd-Doped TiO2 Ellipsoidal Nanoparticles Boosts T1 Contrast Enhancement for Magnetic Resonance Imaging. Nano Lett. 2022, DOI: 10.1021/acs.nanolett.1c04676
4. Liu, K.; Kang, B.; Luo, X.; Yang, Z.; Sun, C.; Li, A.; Fan, Y.; Chen, X.; Gao, J.*; Lin, H.* Redox-Activated Contrast-Enhanced T1-Weighted Imaging Visualizes Glutathione-Mediated Biotransformation Dynamics in the Liver. ACS Nano 2021, 15, 11831-11841.
5. Li, A.; Luo, X.; Li, L.; Chen, D.; Liu, X.; Yang, Z.; Yang, L.; Gao, J.*; Lin, H.* Activatable Multiplexed 19F Magnetic Resonance Imaging Visualizes Reactive Oxygen and Nitrogen Species in Drug-Induced Acute Kidney Injury. Anal. Chem. 2021, 93, 16552-16561.
6. Yang, Z.; Luo, X.; Lin, Y.; Huang, J.; Lin, H.*; Gao, J.* Tandem Chemoimmunotherapy by a Cascade-Responsive Molecular Prodrug. ACS Chem. Biol. 2022, 17, 762-767.
7. Luo, X.#; Gong, X.#; Su, L.#; Lin, H.#; Yang, Z.; Yan, X.; Gao, J.* Activatable Mitochondria-Targeting Organoarsenic Prodrugs for Bioenergetic Cancer Therapy. Angew. Chem. Int. Ed. 2021, 60, 1403-1410.
8. Shi, C.; Zhou, Z.*; Lin, H.*; Gao, J.* Imaging Beyond Seeing: Early Prognosis of Cancer Treatment. Small Methods 2021, 5, 2001025.
9. Luo, X.#; Chi, X.#; Lin, Y.; Yang, Z.; Lin, H.*; Gao, J.* A Camptothecin Prodrug Induces Mitochondria-Mediated Apoptosis in Cancer Cells with Cascade Activations. Chem. Commun. 2021, 57, 11033-11036.
10. Li, A.; Li, L.; Liu, X.; Chen, D.; Fan, Y.; Lin, H.*; Gao, J.* Deep-Tissue Real-Time Imaging of Drug-Induced Liver Injury with Peroxynitrite-Responsive 19F MRI Nanoprobes. Chem. Commun. 2021, 57, 9622-9625.
11. Tang, X.; Gong, X.; Ming, J.; Chen, D.; Lin, H.*; Gao, J.* Fluorinated Gadolinium Chelate-Grafted Nanoconjugates for Contrast-Enhanced T1-Weighted 1H and pH-Activatable 19F Dual-Modal MRI. Anal. Chem. 2020, 92, 16293-16300.
12. Chen, H.#; Tang, X.#; Gong, X.; Chen, D.; Li, A.; Sun, C.; Lin, H.*; Gao, J.* Reversible Redox-Responsive 1H/19F MRI Molecular Probes. Chem. Commun. 2020, 56, 4106-4109.
13. Li, A.#; Tang, X.#; Gong, X.; Chen, H.; Lin, H.*; Gao, J.* A Fluorinated Bihydrazide Conjugate for Activatable Sensing and Imaging of Hypochlorous Acid by 19F NMR/MRI. Chem. Commun. 2019, 55, 12455-12458.
14. Wang, L.#; Lin, H.#; Chi, X.#; Sun, C.#; Huang, J.; Tang, X.; Chen, H.; Luo, X.; Yin, Z.; Gao, J.* A Self-Assembled Biocompatible Nanoplatform for Multimodal MR/Fluorescence Imaging Assisted Photothermal Therapy and Prognosis Analysis. Small 2018, 14, 1801612.
15. Long, M. J.#; Lin, H.-Y.#; Parvez, S.; Zhao, Y.; Poganik, J. R.; Huang, P.; Aye, Y.* Beta-TrCP1 Is a Vacillatory Regulator of Wnt Signaling. Cell Chem. Biol. 2017, 24, 944-957.
16. Lin, H.-Y.; Haegele, J. A.; Disare, M. T.; Lin, Q.; Aye, Y.* A Generalizable Platform for Interrogating Target- And Signal-Specific Consequences of Electrophilic Modifications in Redox-Dependent Cell Signaling. J. Am. Chem. Soc. 2015, 137, 6232-44.
